Alfa Laval Pharma-line Point of Use

Efficient point of use cooling

• Easy installation: The Pharma-line Point of Use is built as a plug-and-play module
• Hygienic design: Reynolds number >4000 maintained in stand-by with main-line velocity >1 m/s. No internal welds, and fully drainable with no dead legs
• Full supply chain transparency with Alfa Laval Q-doc documentation
• Fast response: Cold purified water is available within seconds
• Minimized waste of purified water due to the low hold-up volume and fast response
• Designed according ASME BPE standards

The Pharma-line Point of Use cooler meets the stringent hygienic standard imposed by both control authorities and industry. With a unique design that gives high shear force and turbulence, it minimizes risk of bio-film build-up and ensures an efficient heat transfer. All product wetted parts in the Pharma-line Point of Use cooler are electropolished and the tubes as seamless. For quick and easy installation, the Pharma-line Point of Use cooler is supplied as a complete insulated module with a pitot tube arrangement and either manual or automatic valves. Installed in a pharmaceutical water system, the Pharma-line Point of Use module can be regarded as a sub-loop of the main loop.

Operating principles

The Pharma-line Point of Use heat exchanger in pharmaceutical industry is made up of three tubes positioned concentrically within each other. The product flows in the middle channel meeting the service media in the inner and outer channel to get full countercurrent flow and thereby efficient heat transfer.

Installed as a complete point-of-use cooler the heat exchanger is kept sanitized all the time. In stand-by mode, part of the hot WFI is taken via the pitot tube for a continuous flow through the heat exchanger. Hot WFI(Water for injection) is possible to take out through the user point. When cold WFI(Water for injection) is needed, the cooling mode is turned on, which closes the recirculation valve and opens the cooling water valve. Cold WFI is available within seconds and there is no need for flushing or draining of the system before drawing WFI or PW.

Standard sizes

The Pharma-line Point of Use is available in three standard sizes with a heat transfer area ranging from 0.3 m² to 0.7 m², allowing a flow rate up to 1200 l/h.